Formulation and evaluation of Lamivudine transferosomal gel
نویسندگان
چکیده
Aim and objective: The aim of the study was to formulate evaluate Transferosomal gel lamivudine.
 Method:Lamivudine transferosomes prepared using thin film hydration method taking span 80, Polyoxyethylene lauryl ether in different proportion. formulation characterised by UV spectroscopy, FTIR, in-vitro drug release, evaluations.
 Results: Total nine formulations were formulated optimised F3 showed entrapment efficiency EE (91.17), %CDR (96.12) small particle size (98.19 nm). SEM optimized lamivudine Transferosomes appeared as spherical, well identified, unilamellar vesicles. further with Poloxamer 407 0.5%, 1% 2% w/w ,HPMC k15, Propylene glycol, DMSO. Among these 2%w/w transferosomal is transferosmal Spreadability value 6.01±0.12 cm, pH 5.01 ±0.47. actual content found be 97.29 ±0.66%, which represents good uniformity. viscosity 5960 ±0.75cps. percentage release for 97.31 %. stability studies that more stable at 4˚C when compared other temperatures. future scope perform In Vivo potency formulation.
 Keywords: Lamivudine gel, Transferosomes, Topical, Anti-viral drug, Thin Film Hydration Technique.
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2022
ISSN: ['2250-1177']
DOI: https://doi.org/10.22270/jddt.v12i4-s.5768